In children with bacterial meningitis, nontypical CSF findings and, in particular, normal CSF leukocyte count and increased protein level may indicate a worse prognosis.īacterial meningitis cerebrospinal fluid children prognosis.Ĭopyright © 2014. Patients with meningitis caused by Streptococcus pneumoniae and hyponatremia were at a higher risk of mortality and the development of sequelae. Acute bacterial meningitis is rapidly progressive bacterial infection of the meninges and subarachnoid space. In logistic regression analysis, a normal CSF leukocyte count and increased CSF protein level were related to poor outcomes. In CSF examinations, 16.2% of patients had normal white blood cell counts, 29.5% had normal glucose levels, 24.5% had normal protein levels, 10.2% had normal results in two items, and 8.6% had normal results in all three items. The correlations between the laboratory results and the outcomes were analyzed.Ī total of 175 children with confirmed bacterial meningitis were enrolled. The patients were divided into "normal" and "abnormal" groups for each laboratory result and in combination. This study enrolled CSF culture-proven bacterial meningitis patients aged from 1 month to 18 years in a medical center. To better understand the correlation between CSF results and outcomes, we evaluated CSF data focusing on the patients with atypical findings. However, some patients do not have typical findings and are at a higher risk of being missed or having delayed treatment. (2000) Cerebrospinal fluid findings in aseptic versus bacterial meningitis. The classic CSF abnormalities in bacterial meningitis are a polymorphonuclear leukocytosis, decreased glucose concentration, and increased protein concentration. All contacts should be educated about the signs and symptoms of the infection and when to return to the emergency department.Cerebrospinal fluid (CSF) cell count and biochemical examinations and cultures form the basis for the diagnosis of bacterial meningitis. monocytogenesis an important exception, with approximately 60 of cases having a leukocyte count of <1000 cells/L, which may be lymphocytic. Bacterial: Neonatal (3/12) Gram negative (E coli)(Pseudomonas), Listeria, Group B strep, Coag ve staphylococcus 3/12 to 15 years Neiserria meningitidis, Pneumococcus (strep pneumonia. Change the following lines: BackgroundReports on typical routine cerebrospinal fluid (CSF) findings. Family members should be educated about the need for prophylaxis when there is a family member with Neisseria and H. Infective Bacterial Aseptic Viral, TB, Fungi, Parasites Non-infective Malignancy Auto-immune Age-related Causes of Meningitis. Across the board, the incidence of meningitis has decreased with the implementation of generalized vaccination. All healthcare workers (nurses, physicians, and pharmacists) should educate patients and parents in regards to vaccine-preventable meningitis ( H. To prevent this infection, the education of the public is vital. The pharmacist, preferably specializing in infectious diseases, should assist the clinical team in choosing the appropriate antibiotics based on the age of the patient and local sensitivities and correct dosing to ensure penetration into the central nervous system. If bacterial meningitis is suspected, prompt antibiotics should be started even in the absence of laboratory results. Other specialists who are usually involved in the care of these patients are neurologists, pediatricians, intensivists, infectious disease specialists, and pharmacists. The triage nurse must be fully aware of the signs and symptoms of the illness and refer the patient immediately to the emergency department clinician. The majority of patients with meningitis first present to the emergency department and a streamlined interprofessional approach is vital if one wants to lower the high morbidity. Meningitis is a serious disorder with high morbidity and mortality. cated by the fact that clinical findings do not reliably differentiate bacterial meningitis from other illnesses such as aseptic (viral) meningitis.
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